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Your risk of having bleeding problems is higher than the possible benefit of treatmentYour healthcare provider will decide if COUMADIN is right for youyou are pregnant unless you have a mechanical heart valveCOUMADIN may cause birth defectsmiscarriageor death of your unborn babyyou are allergic to warfarin or any of the other ingredients in COUMADINSee the end of this leaflet for a complete lis t of ingredients in COUMADIN.

Few adequatewell-controlled studies evaluating the potential for metabolic and/or pharmacologic interactions between botanicals and COUMADIN existDue to a lack of manufacturing standardization with botanical medicinal preparationsthe amount of active ingredients may varyThis could further confound the ability to assess potential interactions and effects on anticoagulation.

The appropriate initial dosing of COUMADIN varies widely for different patientsNot all factors responsible for warfarin dose variability are knownand the initial dose is influenced by:

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